Background: academic well-being can stimulate students’,interest, increase their desire to search, and enhance their curiosity to discover new ideas and expanding beliefs and ideas. Students’,academic resilience was examined as a mediating factor in the relationship between a Healthy academic lifestyle and academic well-being in high school. Methods: The study method was descriptive-correlational. The statistical population comprised all high-school male students in Khorramabad (Iran) in 2021, of whom a sample of 400 was selected using multistage random cluster sampling. The suggested model was put to the test using structural equation modeling (SEM). Data analysis was performed in SPSS and AMOS 23. Results: It was discovered that students’,well-being in school was correlated with their Health in school, as well as their resilience in school. There was a negative association between academic inhibiting behaviors and academic well-being (β, =-0. 09,P=0. 041) in the students. academic resilience and academic well-being were shown to have a direct correlation (β, =0. 61,P0. 001) in the students. Also, students’,academic resilience was associated with both Health-promoting (β, =0. 12,P=0. 011) and Health-inhibiting (β, =-0. 18,P=0. 002) activities. academic resilience had a mediating role in the association between Health-oriented academic lifestyle and academic well-being in high school students (P<0. 001). Conclusions: Moreover, the model had a good fit to the data. School principals and teachers should improve students’,Healthpromoting behaviors by increasing motivational and emotional variables (resilience).